Translational Cancer Research 2

Detailed translational pipeline definitions:

T1 – Translation to humans

  • Developing treatments and interventions
  • The translation of basic research into research with humans. Basic research could cover a range of disciplines including laboratory research, epidemiology, psychometrics, social science
  • The interface between basic research and the clinical setting, striving to find how new knowledge of disease mechanisms can be developed into clinically relevant understandings, and
    diagnostic and treatment regimes to be trialled in humans
  • Types of studies/activities – Observational studies, Case studies; Phase I and II clinical trials

T2 – Translation to patients

  • Testing the efficacy and effectiveness of these treatments and interventions
  • The translation of new clinical science and knowledge into routine clinical practice and health decision making1
  • The application of information and insights derived from basic, clinical and population health research to the provision of health services2
  • Translation of new clinically proven knowledge of disease processes, diagnostic or treatment techniques into routine clinical practice and health decision making
  • Types of studies/activities – Phase III clinical trials; observational studies; evidence synthesis and guidelines development

T3 – Translation to practice

  • Dissemination and implementation research for system-wide change2
  • Moving evidence-based guidelines into health practice through delivery, dissemination, and diffusion research
  • Practice-based research where the evidence from clinical trials on carefully selected patients is translated into guidelines for complex patients seen routinely in practice
  • Types of studies/activities – dissemination research; implementation research; diffusion research, Phase IV clinical trials

Grimshaw et al, 2012.

All content reproduced with permission of the Cancer Institute NSW.